I’ll start by saying that I’d get rid of the need to shit. I’m pretty sure everyone can agree that it’s unpleasant.
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Sneezing/snot production. Sure, it can feel amazing. But the sudden urgency to stop everything I’m doing and focus on my nose or risk a disgusting eruption of green mucus all over my face in a public setting is something I could do without.
Also, I’m waiting for someone with medical knowledge to come in here and mention Prions or something else silently devastating to the body.